Requirements: g++, boost, CUDA (driver+toolkit), Matlab and/or Python (2.7 or 3.x) cd build/linux ./autogen.sh # when building a git version ./configure --with-cuda=/usr/local/cuda \ --with-matlab=/usr/local/MATLAB/R2012a \ --with-python \ --prefix=/usr/local/astra make make install Add /usr/local/astra/lib to your LD_LIBRARY_PATH. Add /usr/local/astra/matlab and its subdirectories (tools, mex) to your matlab path. Add /usr/local/astra/python to your PYTHONPATH. NB: Each matlab version only supports a specific range of g++ versions. Despite this, if you have a newer g++ and if you get errors related to missing GLIBCXX_3.4.xx symbols, it is often possible to work around this requirement by deleting the version of libstdc++ supplied by matlab in MATLAB_PATH/bin/glnx86 or MATLAB_PATH/bin/glnxa64 (at your own risk).